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Amber was a key part of our pig stroke model team. Her project was studying behavioral changes post-stroke and she assisted with histological and MRI studies. This work won her 4th place in the 2013 College of Agricultural and Environmental Sciences Undergraduate Research Symposium Oral Competition (see abstract here). We are going to miss Amber,…
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Utilizing Human, rodent and pig cells, key epigenetic markers are compared to understand how this epignomic system evolved. “Comparative epigenomics reveals regulatory features of the genome that cannot be discerned from sequence comparisons alone.” Read more about it: Comparative Epigenomic Annotation of Regulatory DNA .
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Endocrine active compounds such as estradiol and testosterone can be found throughout our environment in the water supply, food and other avenues. These compounds can lead to abnormal germ cell development, infertility and disease in children. Currently a human germ cell system is unavailable for study. Human embryonic stem cell derived germ cells can be…
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Kaitlin Jones represented the pig stroke model research and development group at this years 2nd Annual College of Agricultural and Environmental Sciences Undergraduate Research Symposium. Her in-depth discussion of the development of the model and the MRI and sensory motor function characterization lead to a 4th place finish in stiff competition. Way to go Kaitlin…
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Learn more about how pig induced pluripotent stem cells may potentially change the landscape of biomedical models. Read about it in the Annals of the New York Academy of Sciences.
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Dr. West was recognized by Diverse Magazine as an Emerging Scholar in 2012. The article profiles him and 11 other emerging scholars from various disciplines. Read more about it at Diverse Magazine Emerging Scholars in 2012.
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For the first time in a non-mammalian species, induced pluripotent stem cells (iPSCs) have been derived in the quail. This intriguing article demonstrates that human reprogramming factors POU5F1, SOX2, NANOG, LIN28, KLF4 and C-MYC are capable of de-differentiating quail fibroblast cells back to a pluripotent state. These quail iPSCs not only have morphology and immunoreactivity…
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Read our landmark paper “Chimeric Pigs Produced from Induced Pluripotent Stem Cells Demonstrate Germline Transmission and No Evidence of Tumor Formation in Young Pigs” published in the journal Stem Cells- one of the leading stem cell journals in the world. This article highlights how stringent analysis of chimeric pigs at multiple ages showed that tumors…
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Come visit the West Lab poster “Pig Induced Pluripotent Stem Cells are Capable of Generating Normal Chimeric Pigs and Undergo Neural Differentiation In Vitro” at the Swine in Biomedical Research Conference 2011 in Chicago (July 17 to 19, 2011). Visit the Swine in Biomedical Research Conference 2011 website.
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The West Lab presented some of their groundbreaking research focusing on tumorigenicity and developmental aspects of chimeric pigs derived from induced pluripotent stem cells. The poster raised a number of critical questions in the field including what aspects enable some iPSCs to be chimeric competent and others are not. The evolving discussion of chimeric competence…
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