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Utilizing Human, rodent and pig cells, key epigenetic markers are compared to understand how this epignomic system evolved. “Comparative epigenomics reveals regulatory features of the genome that cannot be discerned from sequence comparisons alone.” Read more about it: Comparative Epigenomic Annotation of Regulatory DNA .
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Endocrine active compounds such as estradiol and testosterone can be found throughout our environment in the water supply, food and other avenues. These compounds can lead to abnormal germ cell development, infertility and disease in children. Currently a human germ cell system is unavailable for study. Human embryonic stem cell derived germ cells can be…
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Learn more about how pig induced pluripotent stem cells may potentially change the landscape of biomedical models. Read about it in the Annals of the New York Academy of Sciences.
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Read our landmark paper “Chimeric Pigs Produced from Induced Pluripotent Stem Cells Demonstrate Germline Transmission and No Evidence of Tumor Formation in Young Pigs” published in the journal Stem Cells- one of the leading stem cell journals in the world. This article highlights how stringent analysis of chimeric pigs at multiple ages showed that tumors…
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Porcine induced pluripotent stem cells produce chimeric offspring. West FD, Terlouw SL, Kwon DJ, Mumaw JL, Dhara SK, Hasneen K, Dobrinsky JR, Stice SL. Stem Cells Dev. 2010 Aug;19(8):1211-20. Abstract Ethical and moral issues rule out the use of human induced pluripotent stem cells (iPSCs) in chimera studies that would determine the full…
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