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Check our our “current lab members” page to find out what each of us is up to!
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Three dimensional reconstruction of MRI in stoke brain. Scans captured on a Siemens 1.5 Tesla magnet.
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Millions of people each year suffer from neural injury and disease with traumatic brain injury (TBI) and stroke being chief among them. TBI is common in toddler age children that suffer falls from highchairs and stairs, teenagers that compete in football and competitive cheerleading and adults that are in car accidents. Part of the insidiousness…
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Our lab is working with induced pluripotent stem cell-derived neural stem cell lines (HIP-NSCs) in an effort to examine their potential to regenerate damaged brain tissue after a neural injury.
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We try to understand the extent to which our stem cell lines are able to form functional neural cells in the stroke environment.
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Through pigs like these, we are looking to determine if NSCs can survive and integrate into an injury site within the brain. Someday, we hope this type of treatment can be translated to humans!
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Induced pluripotent neural stem cells are transplanted into the penumbra region of the infarct (area of tissue damage) using a stereotaxic injector device.
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These cells come in as many colors as there maybe potential cures discovered by their use. Pig iPSCs: POU5F1 (red), SOX2 (green), DNA (blue).
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…and 29 chimeric pigs were born into the world. This is the first derivation of live chimeric animals generated from iPS cells in any species outside of the mouse.
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