chimera
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For the first time in a non-mammalian species, induced pluripotent stem cells (iPSCs) have been derived in the quail. This intriguing article demonstrates that human reprogramming factors POU5F1, SOX2, NANOG, LIN28, KLF4 and C-MYC are capable of de-differentiating quail fibroblast cells back to a pluripotent state. These quail iPSCs not only have morphology and immunoreactivity…
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Read our landmark paper “Chimeric Pigs Produced from Induced Pluripotent Stem Cells Demonstrate Germline Transmission and No Evidence of Tumor Formation in Young Pigs” published in the journal Stem Cells- one of the leading stem cell journals in the world. This article highlights how stringent analysis of chimeric pigs at multiple ages showed that tumors…
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Come visit the West Lab poster “Pig Induced Pluripotent Stem Cells are Capable of Generating Normal Chimeric Pigs and Undergo Neural Differentiation In Vitro” at the Swine in Biomedical Research Conference 2011 in Chicago (July 17 to 19, 2011). Visit the Swine in Biomedical Research Conference 2011 website.
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The West Lab presented some of their groundbreaking research focusing on tumorigenicity and developmental aspects of chimeric pigs derived from induced pluripotent stem cells. The poster raised a number of critical questions in the field including what aspects enable some iPSCs to be chimeric competent and others are not. The evolving discussion of chimeric competence…
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…and 29 chimeric pigs were born into the world. This is the first derivation of live chimeric animals generated from iPS cells in any species outside of the mouse.
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CNN Health Scientists use pig embryo to create stem cellsScientists appear to have broken another barrier in stem cell research by creating a better research model to study human illnesses – a pig – actually 34 pigs. It’s an important advance for research because pigs are much more like humans than other lab animals are.…
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