pigs
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Through pigs like these, we are looking to determine if NSCs can survive and integrate into an injury site within the brain. Someday, we hope this type of treatment can be translated to humans!
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Read our landmark paper “Chimeric Pigs Produced from Induced Pluripotent Stem Cells Demonstrate Germline Transmission and No Evidence of Tumor Formation in Young Pigs” published in the journal Stem Cells- one of the leading stem cell journals in the world. This article highlights how stringent analysis of chimeric pigs at multiple ages showed that tumors…
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The West Lab presented some of their groundbreaking research focusing on tumorigenicity and developmental aspects of chimeric pigs derived from induced pluripotent stem cells. The poster raised a number of critical questions in the field including what aspects enable some iPSCs to be chimeric competent and others are not. The evolving discussion of chimeric competence…
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These cells come in as many colors as there maybe potential cures discovered by their use. Pig iPSCs: POU5F1 (red), SOX2 (green), DNA (blue).
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…and 29 chimeric pigs were born into the world. This is the first derivation of live chimeric animals generated from iPS cells in any species outside of the mouse.
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Dr. West gave a talk at the January Business meeting of the ARCS Foundation Atlanta Chapter. He discussed his groundbreaking work in the differentiation of stem cells into sperm cell and the derivation of induced pluripotent stem cells from pigs. He outlined the potential of using stem cell derived germ cells to screen for toxic…
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Porcine induced pluripotent stem cells produce chimeric offspring. West FD, Terlouw SL, Kwon DJ, Mumaw JL, Dhara SK, Hasneen K, Dobrinsky JR, Stice SL. Stem Cells Dev. 2010 Aug;19(8):1211-20. Abstract Ethical and moral issues rule out the use of human induced pluripotent stem cells (iPSCs) in chimera studies that would determine the full…
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