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The West Lab presented some of their groundbreaking research focusing on tumorigenicity and developmental aspects of chimeric pigs derived from induced pluripotent stem cells. The poster raised a number of critical questions in the field including what aspects enable some iPSCs to be chimeric competent and others are not. The evolving discussion of chimeric competence…
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These cells come in as many colors as there maybe potential cures discovered by their use. Pig iPSCs: POU5F1 (red), SOX2 (green), DNA (blue).
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…and 29 chimeric pigs were born into the world. This is the first derivation of live chimeric animals generated from iPS cells in any species outside of the mouse.
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Dr. West gave a talk at the January Business meeting of the ARCS Foundation Atlanta Chapter. He discussed his groundbreaking work in the differentiation of stem cells into sperm cell and the derivation of induced pluripotent stem cells from pigs. He outlined the potential of using stem cell derived germ cells to screen for toxic…
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Georgia Trend Magazine Jerry Grillo, September 2010 Two UGA scientists make a remarkable breakthrough Reproduction can be pressing business, fraught with challenges. But two University of Georgia scientists made a breakthrough discovery in reproduction and regeneration that has thrown open the doors to wide-ranging possibilities, including new therapies for devastating human diseases and the preservation…
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Porcine induced pluripotent stem cells produce chimeric offspring. West FD, Terlouw SL, Kwon DJ, Mumaw JL, Dhara SK, Hasneen K, Dobrinsky JR, Stice SL. Stem Cells Dev. 2010 Aug;19(8):1211-20. Abstract Ethical and moral issues rule out the use of human induced pluripotent stem cells (iPSCs) in chimera studies that would determine the full…
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CNN Health Scientists use pig embryo to create stem cellsScientists appear to have broken another barrier in stem cell research by creating a better research model to study human illnesses – a pig – actually 34 pigs. It’s an important advance for research because pigs are much more like humans than other lab animals are.…
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